Depression affects millions of people every year. For some people, regular antidepressants do not provide enough relief. This condition is called treatment-resistant depression.
Spravato® (esketamine) is a newer treatment option that has helped many people when other medications have not worked. It is FDA-approved and given as a nasal spray under medical supervision. While Spravato can be very effective, it is important to understand its side effects and know what to expect during treatment.
Most side effects are mild and temporary. Knowing about them ahead of time can help you feel more prepared and comfortable.
What Is Spravato and How Does It Work?
Spravato contains esketamine, a medication that works differently from traditional antidepressants. It affects glutamate, a chemical messenger in the brain that plays a role in mood and learning.
Many antidepressants take time to work. Spravato may help some people feel better sooner. Since it can cause side effects, treatment is given only by trained healthcare providers in certified clinics. Patients receive the nasal spray at the clinic and remain under observation for at least two hours after each session.
Common Spravato Side Effects
Many people tolerate Spravato well. However, some side effects are common, especially during the first few treatments.
Dizziness
Feeling dizzy or lightheaded is one of the most common side effects. This usually improves within a few hours.
Sleepiness
Many patients feel tired or sleepy after treatment. Because of this, you should avoid driving until the next day after a full night’s sleep.
Nausea and Vomiting
Some patients experience nausea. A smaller number may vomit. Your provider may recommend avoiding large meals before treatment.
Feeling Detached or Dream-Like
Spravato can cause dissociation. This means you may feel disconnected from yourself or your surroundings. Some people describe the experience as feeling dreamy or floating. These feelings are temporary and usually go away before leaving the clinic.
Headache
Headaches may occur after treatment. Drinking water and resting often help.
Anxiety
Some patients feel nervous or restless during treatment. Having a calm and comfortable environment can help reduce anxiety.
Studies found that dizziness, nausea, sleepiness, headaches, and feeling disconnected from your surroundings were some of the most common side effects.
Serious Spravato Side Effects
Serious side effects are uncommon, but patients should know about them.
Increased Blood Pressure
Spravato may temporarily raise blood pressure. Healthcare providers check blood pressure before and after treatment to help reduce risks.
Severe Drowsiness
Some patients become very sleepy. This is one reason patients stay at the clinic for monitoring.
Trouble Breathing
Rare breathing problems can occur. Medical staff observe patients throughout the treatment period to ensure safety.
Changes in Mood
Like other antidepressants, Spravato may cause suicidal thoughts in some people. This risk is higher when treatment first starts. Contact your healthcare provider right away if your mood gets worse or changes suddenly.
Risk of Misuse
Because esketamine is related to ketamine, there is a risk of misuse. To keep patients safe, Spravato is only available through a special FDA safety program called REMS.
What Happens During a Spravato Treatment Session?
Knowing what to expect can make treatment less stressful.
Before Treatment
Your provider will review your health history and check your blood pressure. You may be asked not to eat for two hours before your appointment.
During Treatment
You will use the nasal spray under supervision. Most patients sit in a comfortable chair and relax while the medication takes effect.
Observation Period
You will remain at the clinic for at least two hours. Medical staff will monitor your blood pressure and any side effects. You should arrange for someone else to drive you home.
At ORIGEN Healthcare, patient comfort and safety are always a priority.
How Long Do Spravato Side Effects Last?
One of the most common questions patients ask is how long side effects last. For most people, side effects begin shortly after treatment and improve within several hours. By the next day, many patients feel back to normal.
The first few sessions may cause stronger side effects. Over time, some people notice that symptoms become milder as their body adjusts. Every patient is different. Your experience may not be the same as someone else’s.
Tips for Managing Spravato Side Effects
Simple steps can help you feel more comfortable after treatment.
Drink Plenty of Water
Staying hydrated may help reduce headaches and dizziness.
Eat Light Meals
Avoid heavy meals before treatment. This may help reduce nausea.
Plan for Rest
Take it easy after your appointment. Avoid work, driving, or important decisions until the next day.
Arrange Transportation
Always have someone drive you home after treatment.
Communicate With Your Provider
Tell your healthcare team about any symptoms that concern you. They can help manage side effects and answer your questions.
When Should You Call Your Doctor?
Seek medical attention right away if you experience:
- Trouble breathing
- Severe chest pain
- Extreme confusion
- Severe dizziness
- Allergic reactions
- Worsening depression
- Thoughts of self-harm
- Sudden mood changes
Getting prompt care can help prevent serious complications.
Is Spravato Safe?
Spravato is safe for many adults when given by trained providers. Patients receive treatment in certified clinics where they can be monitored for safety.
Studies and FDA reviews show that Spravato has helped many people who did not get enough relief from regular antidepressants. Every person’s situation is unique. Your healthcare provider can determine whether Spravato is right for you.
Conclusion
Spravato offers hope to many people living with treatment-resistant depression. Like all medications, it can cause side effects. Most side effects are temporary and improve within hours. Common symptoms include dizziness, nausea, headache, sleepiness, and feelings of dissociation. Serious side effects are rare but require medical supervision. Receiving treatment in a certified clinic helps ensure your safety and peace of mind.
At ORIGEN Healthcare in Omaha, Nebraska, Dr. Nazira Usmanova and her caring team help children and adults with mental health care. If you have depression and other medicines have not helped, Spravato may be an option for you. Contact ORIGEN Healthcare today to learn more and see if this treatment is right for you.
